HYPO Hypoxia-induced Factor Content in Neurons of the Parietal Cortex and Hippocampus of Rats with Cerebral Ischemia of Various Severity
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Abstract
Cerebral ischemia, including strokes, is one of the leading causes of disability and death in the world.
Despite advances in medicine, many cases of cerebral ischemia remain undiagnosed or misdiagnosed. This highlights the need to study the mechanisms associated with hypoxia and develop new therapeutic approaches for the treatment of strokes and other diseases associated with insufficient blood supply. Adaptation to ischemic conditions is represented by an increase in the production of induced factor 1-α in neurons of the brain.
Its expression increases with a decrease in the amount of oxygen in the blood. In this study, the content of hypoxia-induced factor 1-α in neurons of the parietal cortex and hippocampus of rats with cerebral ischemia of varying severity was assessed.
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